Monoclonal Light Chain Nephropathy: A Potential Diagnostic Delay
نویسندگان
چکیده
منابع مشابه
Diagnostic accuracy of monoclonal antibody based serum immunoglobulin free light chain immunoassays in myeloma cast nephropathy
UNLABELLED BACKGROUND The development of serum immunoassays for the measurement of immunoglobulin free light chains has led to a paradigm shift in the diagnosis, assessment and monitoring of patients with plasma cell dyscrasias. The impact of these immunoassays which employ polyclonal antibodies was most notable for those patients who were previously classified as non-secretory multiple myel...
متن کاملLymphoplasmacytic lymphoma causing light chain cast nephropathy.
Plasma cell dyscrasias are frequently associated with kidney disease through the production of monoclonal immunoglobulin but with a diverse set of pathologic renal patterns. While almost all patients with a renal biopsy showing a cast nephropathy have myeloma, kidney involvement associated with pathological immunoglobulin light chains and lymphoma is rare. To our knowledge, this is the first re...
متن کاملHeavy/Light-chain analysis of monoclonal gammopathies.
Monoclonal gammopathies (M proteins) are associated with an extraordinarily broad array of clinical conditions that range from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma. Three basic goals of the methods used to investigate M proteins are detection, immunochemical characterization, and quantification. Serum protein electrophoresis (SPE) techniques have undergo...
متن کاملMonoclonal vs polyclonal free light chain assays.
Am J Clin Pathol 2009;131:897-903 901 © American Society for Clinical Pathology relative to Freelite (Figure 1). Both patients had negative results for urine BJPs, further undermining the validity of the ELISA assay results. It is possible that the monoclonal antibodies are cross-reacting with the reported IgG λ and IgA λ monoclonal intact immunoglobulins in these patients, leading to falsely r...
متن کاملLight-chain nephropathy in patient with renal carcinoma.
Paraneoplastic syndromes are often associated with renal parenchymal tumours. This report describes a case of renal-cell carcinoma with kappa-chain nephropathy. The patient, a 60-year-old man, had renal tubular dysfunction, shown by low serum concentrations of urate and phosphate. Kappa-chains were found in both serum and urine, but no lambda-chains were found. Investigations showed a clear-cel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Medical Student Research Journal
سال: 2015
ISSN: 2333-4096
DOI: 10.15422/amsrj.2015.03.023